ea0034p235 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2014
Leiter Sarah
, Minic Marina
, Parker Victoria
, Harris Julie
, Hamilton-Shield Julian
, Williams Rachel
, Korsch Eckhard
, Hussain Khalid
, Semple Robert
Congenital hyperinsulinaemic hypoglycaemia is generally characterised by low levels of ketone bodies, fatty acids and branched chain amino acids at the time of severe hypoglycaemia, and by a requirement for a relatively high rate of glucose infusion (>10 mg/kg per min) to maintain euglycaemia. It is caused by physiologically inappropriate insulin secretion from the pancreatic beta cells due to mutations that uncouple insulin secretion from normal hyperglycaemic and other s...